jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2023-15-4-14-24jofin-1563Research ArticleОбзорReviewВысокопатогенный грипп Н5: риски формирования нового пандемического штаммаHighly pathogenic influenza H5: risks of a new pandemic strain developingДаниленкоД. М.DanilenkoD. M.

Даниленко Дарья Михайловна – заместитель  директора по научной работе, руководитель отдела  этиологии и эпидемиологии, к.б.н.; тел.: 8(812)449-15-25

Санкт-Петербург

Saint-Petersburg

daria.baibus@gmail.comКомиссаровА. Б.KomissarovA. B.

Комиссаров Андрей Борисович – руководитель  лаборатории молекулярной вирусологии; тел.: 8(812)499-15-18

Санкт-Петербург

Saint-Petersburg

a.b.komissarov@gmail.comПередерийА. А.PerederiyA. A.

Передерий Александр Александрович – лаборант- исследователь лаборатории молекулярной  вирусологии; тел.: 8(812)499-15-26

Санкт-Петербург

Saint-Petersburg

gilagalex@gmail.comФадеевА. В.FadeyevA. V.

Фадеев Артем Викторович – старший научный  сотрудник лаборатории молекулярной вирусологии; тел.: 8(812)499-15-26

Санкт-Петербург

Saint-Petersburg

afadeew@gmail.comЛиозновД. А.LioznovD. A.

Лиознов Дмитрий Анатольевич –директор;

заведующий кафедрой инфекционных болезней и  эпидемиологии, д.б.н.; тел.: 8(812)449-15-00

Санкт-Петербург

Saint-Petersburg

dlioznov@yandex.ruНаучно-исследовательский институт гриппа им. А.А. СмородинцеваРоссияResearch Institute of Influenza named after A.A. SmorodintsevRussian FederationНаучно-исследовательский институт гриппа им. А.А. Смородинцева; Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. ПавловаРоссияResearch Institute of Influenza named after A.A. Smorodintsev; First Saint-Petersburg State Medical University named after Academician I.P. PavlovRussian Federation2023100120241541424Copyright © Даниленко Д.М., Комиссаров А.Б., Передерий А.А., Фадеев А.В., Лиознов Д.А., 20242024Даниленко Д.М., Комиссаров А.Б., Передерий А.А., Фадеев А.В., Лиознов Д.А.Danilenko D.M., Komissarov A.B., Perederiy A.A., Fadeyev A.V., Lioznov D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1563

В обзоре представлены краткие исторические сведения о высокопатогенном гриппе А подтипа H5. Показаны пути формирования потенциально пандемических вирусов и роль низкопатогенных вирусов гриппа в этом процессе. Отдельно внимание уделяется современному состоянию проблемы – распространению вирусов высокопатогенного гриппа подтипа Н5 на территориях, где он ранее не был зарегистрирован, преодолению межвидового барьера, утрате сезонности в циркуляции гриппа Н5, формированию вариантов вируса, имеющих эволюционное преимущество для репликации в организме млекопитающих и человека. Рассмотрены вопросы вакцинации поголовья домашней птицы как средства для снижения интенсивной циркуляции гриппа и проблемы ее внедрения в глобальном масштабе. Кроме того, обсуждаются риски дальнейшего распространения высокопатогенного гриппа и появления пандемических штаммов.

The review provides brief historical information on the highly pathogenic influenza A (H5) and presents data on massive outbreaks caused by this subtype. It includes historical background, data on outbreaks, and the formation of potentially pandemic viruses. The abstract also highlights the current state of the problem, such as the spread of H5 influenza in new territories and its ability to infect mammals and humans. The issues of vaccination for poultry and the challenges of implementing it globally are addressed. Furthermore, the risks of further spread of the virus and the emergence of pandemic strains are being discussed.

высокопатогенный грипп птицизменчивостьпотенциально пандемический штаммриски распространенияhighly pathogenic avian influenzavariabilitypotentially pandemic strainrisk of spreadРабота выполнена при поддержке гранта НЦМУ «Передовые цифровые технологии» (в рамках Соглашения о предоставлении гранта от 20.04.2022 №075-15-2022-313).ReferencesVan Epps HL. Influenza: Exposing the true killer. The Journal of Experimental Medicine. 2006;203(4):803–803. doi:10.1084/jem.2034ftaVan Epps HL. Influenza: Exposing the true killer. The Journal of Experimental Medicine. 2006;203(4):803–803. doi:10.1084/jem.2034ftaSmith W, Andrewes CH, Laidlaw PP. A virus obtained from influenza patients. The Lancet. 1933;222(5732):66–8. doi:10.1016/s0140-6736(00)78541-2Smith W, Andrewes CH, Laidlaw PP. A virus obtained from influenza patients. The Lancet. 1933;222(5732):66–8. doi:10.1016/s0140-6736(00)78541-2Schäfer W. Vergleichende sero-immunologische Untersuchungen über die viren der influenza und klassischen Geflügelpest. Zeitschrift für Naturforschung B. 1955;10(2):81–91. doi:10.1515/znb-1955-0205Schäfer W. Vergleichende sero-immunologische Untersuchungen über die viren der influenza und klassischen Geflügelpest. Zeitschrift für Naturforschung B. 1955;10(2):81–91. doi:10.1515/znb-1955-0205Bouvier NM, Palese P. The biology of influenza viruses. Vaccine. 2008;26. doi:10.1016/j.vaccine.2008.07.039Bouvier NM, Palese P. The biology of influenza viruses. Vaccine. 2008;26. doi:10.1016/j.vaccine.2008.07.039Shao W, Li X, Goraya M, Wang S, Chen J-L. Evolution of influenza A virus by mutation and Re-Assortment. International Journal of Molecular Sciences. 2017;18(8):1650. doi:10.3390/ijms18081650Shao W, Li X, Goraya M, Wang S, Chen J-L. Evolution of influenza A virus by mutation and Re-Assortment. International Journal of Molecular Sciences. 2017;18(8):1650. doi:10.3390/ijms18081650Kilbourne ED. Influenza pandemics of the 20th Century. Emerging Infectious Diseases. 2006;12(1):9–14. doi:10.3201/eid1201.051254Kilbourne ED. Influenza pandemics of the 20th Century. Emerging Infectious Diseases. 2006;12(1):9–14. doi:10.3201/eid1201.051254Zhuang Q, Wang S, Liu S, Hou G, Li J, Jiang W, et al. Diversity and distribution of type A influenza viruses: An updated panorama analysis based on protein sequences. Virology Journal. 2019;16(1). doi:10.1186/s12985-019-1188-7Zhuang Q, Wang S, Liu S, Hou G, Li J, Jiang W, et al. Diversity and distribution of type A influenza viruses: An updated panorama analysis based on protein sequences. Virology Journal. 2019;16(1). doi:10.1186/s12985-019-1188-7Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y. Evolution and ecology of influenza A viruses. Microbiological Reviews. 1992;56(1):152–79. doi:10.1128/mr.56.1.152-179.1992Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y. Evolution and ecology of influenza A viruses. Microbiological Reviews. 1992;56(1):152–79. doi:10.1128/mr.56.1.152-179.1992Tong S, Li Y, Rivailler P, Conrardy C, Castillo DA, Chen L-M, et al. A distinct lineage of influenza a virus from bats. Proceedings of the National Academy of Sciences. 2012;109(11):4269–74. doi:10.1073/pnas.1116200109Tong S, Li Y, Rivailler P, Conrardy C, Castillo DA, Chen L-M, et al. A distinct lineage of influenza a virus from bats. Proceedings of the National Academy of Sciences. 2012;109(11):4269–74. doi:10.1073/pnas.1116200109Tong S, Zhu X, Li Y, Shi M, Zhang J, Bourgeois M, et al. New world bats harbor diverse influenza a viruses. PLoS Pathogens. 2013;9(10). doi:10.1371/journal.ppat.1003657Tong S, Zhu X, Li Y, Shi M, Zhang J, Bourgeois M, et al. New world bats harbor diverse influenza a viruses. PLoS Pathogens. 2013;9(10). doi:10.1371/journal.ppat.1003657Webster RG. Influenza: Searching for pandemic origins. Annual Review of Virology. 2023;10(1):1–23. doi:10.1146/annurev-virology-111821-125223Webster RG. Influenza: Searching for pandemic origins. Annual Review of Virology. 2023;10(1):1–23. doi:10.1146/annurev-virology-111821-125223Krauss S, Webster RG. Avian influenza virus surveillance and wild birds: Past and present. Avian Diseases Digest. 2010;5(s1). doi:10.1637/9107-870309-digest.1Krauss S, Webster RG. Avian influenza virus surveillance and wild birds: Past and present. Avian Diseases Digest. 2010;5(s1). doi:10.1637/9107-870309-digest.1Ramey AM, Reeves AB, Drexler JZ, Ackerman JT, De La Cruz S, Lang AS, et al. Influenza A viruses remain infectious for more than seven months in northern wetlands of North America. Proceedings of the Royal Society B: Biological Sciences. 2020;287(1934):20201680. doi:10.1098/rspb.2020.1680Ramey AM, Reeves AB, Drexler JZ, Ackerman JT, De La Cruz S, Lang AS, et al. Influenza A viruses remain infectious for more than seven months in northern wetlands of North America. Proceedings of the Royal Society B: Biological Sciences. 2020;287(1934):20201680. doi:10.1098/rspb.2020.1680Postnikova Y, Treshchalina A, Boravleva E, Gambaryan A, Ishmukhametov A, Matrosovich M, et al. Diversity and reassortment rate of influenza A viruses in wild ducks and gulls. Viruses. 2021;13(6):1010. doi:10.3390/v13061010Postnikova Y, Treshchalina A, Boravleva E, Gambaryan A, Ishmukhametov A, Matrosovich M, et al. Diversity and reassortment rate of influenza A viruses in wild ducks and gulls. Viruses. 2021;13(6):1010. doi:10.3390/v13061010Becker WB. The isolation and classification of Tern virus: Influenza virus A/tern/south africa/1961. Journal of Hygiene. 1966;64(3):309–20. doi:10.1017/s0022172400040596Becker WB. The isolation and classification of Tern virus: Influenza virus A/tern/south africa/1961. Journal of Hygiene. 1966;64(3):309–20. doi:10.1017/s0022172400040596Alexander DJ, Brown IH. History of highly pathogenic avian influenza. Revue Scientifique et Technique de l’OIE. 2009;28(1):19–38. doi:10.20506/rst.28.1.1856Alexander DJ, Brown IH. History of highly pathogenic avian influenza. Revue Scientifique et Technique de l’OIE. 2009;28(1):19–38. doi:10.20506/rst.28.1.1856Pereira HG, Tůmová B, Law VG. Avian influenza A viruses. Bull World Health Organ. 1965;32(6):855-60Pereira HG, Tůmová B, Law VG. Avian influenza A viruses. Bull World Health Organ. 1965;32(6):855-60Lang G, Narayan O, Rouse BT, Ferguson AE, Connell MC. A new influenza A virus infection in turkeys II. A highly pathogenic variant, a/turkey/ontario 772/66. Can Vet J. 1968 Jul;9(7):151-60Lang G, Narayan O, Rouse BT, Ferguson AE, Connell MC. A new influenza A virus infection in turkeys II. A highly pathogenic variant, a/turkey/ontario 772/66. Can Vet J. 1968 Jul;9(7):151-60Beard CW, Helfer DH. Isolation of two Turkey influenza viruses in Oregon. Avian Diseases. 1972;16(5):1133. doi:10.2307/1588841Beard CW, Helfer DH. Isolation of two Turkey influenza viruses in Oregon. Avian Diseases. 1972;16(5):1133. doi:10.2307/1588841Alexander DJ. A review of avian influenza in different bird species. Veterinary Microbiology. 2000;74(1–2):3–13. doi:10.1016/s0378-1135(00)00160-7Alexander DJ. A review of avian influenza in different bird species. Veterinary Microbiology. 2000;74(1–2):3–13. doi:10.1016/s0378-1135(00)00160-7Monne I, Fusaro A, Nelson MI, Bonfanti L, Mulatti P, Hughes J, et al. Emergence of a highly pathogenic avian influenza virus from a low-pathogenic progenitor. Journal of Virology. 2014;88(8):4375–88. doi:10.1128/jvi.03181-13Monne I, Fusaro A, Nelson MI, Bonfanti L, Mulatti P, Hughes J, et al. Emergence of a highly pathogenic avian influenza virus from a low-pathogenic progenitor. Journal of Virology. 2014;88(8):4375–88. doi:10.1128/jvi.03181-13Seekings AH, Slomka MJ, Russell C, Howard WA, Choudhury B, Nuñéz A, et al. Direct evidence of H7N7 avian influenza virus mutation from low to high virulence on a single poultry premises during an outbreak in free range chickens in the UK, 2008. Infection, Genetics and Evolution. 2018;64:13–31. doi:10.1016/j.meegid.2018.06.005Seekings AH, Slomka MJ, Russell C, Howard WA, Choudhury B, Nuñéz A, et al. Direct evidence of H7N7 avian influenza virus mutation from low to high virulence on a single poultry premises during an outbreak in free range chickens in the UK, 2008. Infection, Genetics and Evolution. 2018;64:13–31. doi:10.1016/j.meegid.2018.06.005Scheibner D, Breithaupt A, Luttermann C, Blaurock C, Mettenleiter TC, Abdelwhab EM. Genetic Determinants for Virulence and Transmission of the Panzootic Avian Influenza Virus H5N8 Clade 2.3.4.4 in Pekin Ducks. J Virol. 2022 Jul 13;96(13):e0014922. doi: 10.1128/jvi.00149-22Scheibner D, Breithaupt A, Luttermann C, Blaurock C, Mettenleiter TC, Abdelwhab EM. Genetic Determinants for Virulence and Transmission of the Panzootic Avian Influenza Virus H5N8 Clade 2.3.4.4 in Pekin Ducks. J Virol. 2022 Jul 13;96(13):e0014922. doi: 10.1128/jvi.00149-22Dhingra MS, Artois J, Dellicour S, Lemey P, Dauphin G, Von Dobschuetz S, et al. Geographical and historical patterns in the emergences of novel highly pathogenic avian influenza (Hpai) H5 and H7 viruses in Poultry. Frontiers in Veterinary Science. 2018;5. doi:10.3389/fvets.2018.00084Dhingra MS, Artois J, Dellicour S, Lemey P, Dauphin G, Von Dobschuetz S, et al. Geographical and historical patterns in the emergences of novel highly pathogenic avian influenza (Hpai) H5 and H7 viruses in Poultry. Frontiers in Veterinary Science. 2018;5. doi:10.3389/fvets.2018.00084Leyson CM, Youk S, Ferreira HL, Suarez DL, PantinJackwood M. Multiple gene segments are associated with enhanced virulence of clade 2.3.4.4 H5N8 highly pathogenic avian influenza virus in Mallards. Journal of Virology. 2021;95(18). doi:10.1128/jvi.00955-21Leyson CM, Youk S, Ferreira HL, Suarez DL, PantinJackwood M. Multiple gene segments are associated with enhanced virulence of clade 2.3.4.4 H5N8 highly pathogenic avian influenza virus in Mallards. Journal of Virology. 2021;95(18). doi:10.1128/jvi.00955-21Bertram S, Glowacka I, Steffen I, Kühl A, Pöhlmann S. Novel insights into proteolytic cleavage of influenza virus hemagglutinin. Reviews in Medical Virology. 2010;20(5):298–310. doi:10.1002/rmv.657Bertram S, Glowacka I, Steffen I, Kühl A, Pöhlmann S. Novel insights into proteolytic cleavage of influenza virus hemagglutinin. Reviews in Medical Virology. 2010;20(5):298–310. doi:10.1002/rmv.657Zhirnov OP, Vorobjeva IV, Ovcharenko AV, Klenk HD. Biochemistry (Moscow). 2003;68(9):1020–6. doi:10.1023/a:1026020831036Zhirnov OP, Vorobjeva IV, Ovcharenko AV, Klenk HD. Biochemistry (Moscow). 2003;68(9):1020–6. doi:10.1023/a:1026020831036Decha P, Rungrotmongkol T, Intharathep P, Malaisree M, Aruksakunwong O, Laohpongspaisan C, et al. Source of high pathogenicity of an avian influenza virus H5N1: Why H5 is better cleaved by furin. Biophysical Journal. 2008;95(1):128–34. doi:10.1529/biophysj.107.127456Decha P, Rungrotmongkol T, Intharathep P, Malaisree M, Aruksakunwong O, Laohpongspaisan C, et al. Source of high pathogenicity of an avian influenza virus H5N1: Why H5 is better cleaved by furin. Biophysical Journal. 2008;95(1):128–34. doi:10.1529/biophysj.107.127456Alexander DJ, Brown IH. History of highly pathogenic avian influenza. Revue Scientifique et Technique de l’OIE. 2009;28(1):19–38. doi:10.20506/rst.28.1.1856ALEXANDER DJ, BROWN IH. History of highly pathogenic avian influenza. Revue Scientifique et Technique de l’OIE. 2009;28(1):19–38. doi:10.20506/rst.28.1.1856Duan L, Campitelli L, Fan XH, Leung YH, Vijaykrishna D, Zhang JX, et al. Characterization of low-pathogenic H5 subtype influenza viruses from Eurasia: Implications for the origin of highly pathogenic H5N1 viruses. Journal of Virology. 2007;81(14):7529–39. doi:10.1128/jvi.00327-07Duan L, Campitelli L, Fan XH, Leung YH, Vijaykrishna D, Zhang JX, et al. Characterization of low-pathogenic H5 subtype influenza viruses from Eurasia: Implications for the origin of highly pathogenic H5N1 viruses. Journal of Virology. 2007;81(14):7529–39. doi:10.1128/jvi.00327-07Claas EC, Osterhaus AD, van Beek R, De Jong JC, Rimmelzwaan GF, Senne DA, et al. Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. The Lancet. 1998;351(9101):472–7. doi:10.1016/s0140-6736(97)11212-0Claas EC, Osterhaus AD, van Beek R, De Jong JC, Rimmelzwaan GF, Senne DA, et al. Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. The Lancet. 1998;351(9101):472–7. doi:10.1016/s0140-6736(97)11212-0Chan PK. Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997. Clinical Infectious Diseases. 2002;34(Supplement_2). doi:10.1086/338820Chan PK. Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997. Clinical Infectious Diseases. 2002;34(Supplement_2). doi:10.1086/338820Wan X-F, Dong L, Lan Y, Long L-P, Xu C, Zou S, et al. Indications that live poultry markets are a major source of human H5N1 influenza virus infection in China. Journal of Virology. 2011;85(24):13432–8. doi:10.1128/jvi.05266-11Wan X-F, Dong L, Lan Y, Long L-P, Xu C, Zou S, et al. Indications that live poultry markets are a major source of human H5N1 influenza virus infection in China. Journal of Virology. 2011;85(24):13432–8. doi:10.1128/jvi.05266-11Rogers GN, Paulson JC. Receptor determinants of human and animal influenza virus isolates: Differences in receptor specificity of the H3 hemagglutinin based on species of origin. Virology. 1983;127(2):361–73. doi:10.1016/0042-6822(83)90150-2Rogers GN, Paulson JC. Receptor determinants of human and animal influenza virus isolates: Differences in receptor specificity of the H3 hemagglutinin based on species of origin. Virology. 1983;127(2):361–73. doi:10.1016/0042-6822(83)90150-2Chan RWY, Chan MCW, Nicholls JM, Malik Peiris JS. Use of ex vivo and in vitro cultures of the human respiratory tract to study the tropism and host responses of highly pathogenic avian influenza A (H5N1) and other influenza viruses. Virus Research. 2013;178(1):133–45. doi:10.1016/j.virusres.2013.03.003Chan RWY, Chan MCW, Nicholls JM, Malik Peiris JS. Use of ex vivo and in vitro cultures of the human respiratory tract to study the tropism and host responses of highly pathogenic avian influenza A (H5N1) and other influenza viruses. Virus Research. 2013;178(1):133–45. doi:10.1016/j.virusres.2013.03.003Zhao H, Zhou J, Jiang S, Zheng B-J. Receptor binding and transmission studies of H5N1 influenza virus in mammals. Emerging Microbes & Infections. 2013;2(1):1–5. doi:10.1038/emi.2013.89Zhao H, Zhou J, Jiang S, Zheng B-J. Receptor binding and transmission studies of H5N1 influenza virus in mammals. Emerging Microbes & Infections. 2013;2(1):1–5. doi:10.1038/emi.2013.89Cauthen AN, Swayne DE, Schultz-Cherry S, Perdue ML, Suarez DL. Continued circulation in China of highly pathogenic avian influenza viruses encoding the hemagglutinin gene associated with the 1997 H5N1 outbreak in poultry and humans. Journal of Virology. 2000;74(14):6592–9. doi:10.1128/jvi.74.14.6592-6599.2000Cauthen AN, Swayne DE, Schultz-Cherry S, Perdue ML, Suarez DL. Continued circulation in China of highly pathogenic avian influenza viruses encoding the hemagglutinin gene associated with the 1997 H5N1 outbreak in poultry and humans. Journal of Virology. 2000;74(14):6592–9. doi:10.1128/jvi.74.14.6592-6599.2000Ellis TM, Barry Bousfield R, Bissett LA, Dyrting KC, Luk GS, Tsim ST, et al. Investigation of outbreaks of highly pathogenic H5N1 avian influenza in waterfowl and wild birds in Hong Kong in late 2002. Avian Pathology. 2004;33(5):492–505. doi:10.1080/03079450400003601Ellis TM, Barry Bousfield R, Bissett LA, Dyrting KC, Luk GS, Tsim ST, et al. Investigation of outbreaks of highly pathogenic H5N1 avian influenza in waterfowl and wild birds in Hong Kong in late 2002. Avian Pathology. 2004;33(5):492–505. doi:10.1080/03079450400003601Львов Д. К. Новые и возвращающиеся инфекции - дремлющий вулкан // Проблемы особо опасных инфекций. -2008. -№2. – С. 5-8.L’vov DK. Emerging and re-emerging infections - a dozing volcano. Problems of Particularly Dangerous Infections. 2008;(2(96)):5–8. doi:10.21055/0370-1069-2008-2(96)-5-8 (in Russian)Smith GJ, Donis RO. Nomenclature updates resulting from the evolution of avian influenza A(H5) virus clades 2.1.3.2a, 2.2.1, and 2.3.4 during 2013–2014. Influenza and Other Respiratory Viruses. 2015;9(5):271–6. doi:10.1111/irv.12324Smith GJ, Donis RO. Nomenclature updates resulting from the evolution of avian influenza A(H5) virus clades 2.1.3.2a, 2.2.1, and 2.3.4 during 2013–2014. Influenza and Other Respiratory Viruses. 2015;9(5):271–6. doi:10.1111/irv.12324К.А. Шаршов, В.Ю. Марченко, А.К. Юрлов, А.М. Шестопалов. Экология и эволюция высокопатогенного вируса гриппа H5N1 в России (2005-2012 гг.) // Бюллетень ВСНЦ СО РАН. -2012. -№5. -С. 393-396.K.A. Sharshov, V.Yu. Marchenko, A.K. Yurlov, A.M. Shestopalov Ecology and evolution of highly pathogenic avian influenza H5N1in Russia (2005–2012). Acta Biomedica Scientifica. 2012. №5-1 (87). (in Russian)Human infection with avian influenza A(H5) viruses. URL: https://cdn.who.int/media/docs/default-source/wpro--documents/emergency/surveillance/avian-influenza/ai_20231110.pdf?sfvrsn=5f006f99_122#:~:text=Globally%2C%20from%20January%202003%20to,of%2052%25)%20(Source)Human infection with avian influenza A(H5) viruses. URL: https://cdn.who.int/media/docs/default-source/wpro--documents/emergency/surveillance/avian-influenza/ai_20231110.pdf?sfvrsn=5f006f99_122#:~:text=Globally%2C%20from%20January%202003%20to,of%2052%25)%20(Source)Marchenko VY, Susloparov IM, Kolosova NP, Goncharova NI, Shipovalov AV, Durymanov AG, et al. Influenza A(H5N8) virus isolation in Russia, 2014. Archives of Virology. 2015;160(11):2857–60. doi:10.1007/s00705-015-2570-4Marchenko VY, Susloparov IM, Kolosova NP, Goncharova NI, Shipovalov AV, Durymanov AG, et al. Influenza A(H5N8) virus isolation in Russia, 2014. Archives of Virology. 2015;160(11):2857–60. doi:10.1007/s00705-015-2570-4Pasick J, Berhane Y, Joseph T, Bowes V, Hisanaga T, Handel K, et al. Reassortant highly pathogenic influenza A H5N2 virus containing gene segments related to Eurasian H5N8 in British Columbia, Canada, 2014. Scientific Reports. 2015;5(1). doi:10.1038/srep09484Pasick J, Berhane Y, Joseph T, Bowes V, Hisanaga T, Handel K, et al. Reassortant highly pathogenic influenza A H5N2 virus containing gene segments related to Eurasian H5N8 in British Columbia, Canada, 2014. Scientific Reports. 2015;5(1). doi:10.1038/srep09484Scheibner D, Breithaupt A, Luttermann C, Blaurock C, Mettenleiter TC, Abdelwhab EM. Genetic determinants for virulence and transmission of the panzootic avian influenza virus H5N8 clade 2.3.4.4 in Pekin ducks. Journal of Virology. 2022;96(13). doi:10.1128/jvi.00149-22Scheibner D, Breithaupt A, Luttermann C, Blaurock C, Mettenleiter TC, Abdelwhab EM. Genetic determinants for virulence and transmission of the panzootic avian influenza virus H5N8 clade 2.3.4.4 in Pekin ducks. Journal of Virology. 2022;96(13). doi:10.1128/jvi.00149-22Greene, J. L. 2015. Update on the highly-pathogenic avian influenza outbreak of 2014–2015. https://nationalaglawcenter.org/wp-content/uploads/assets/crs/R44114.pdfGreene, J. L. 2015. Update on the highly-pathogenic avian influenza outbreak of 2014–2015. https://nationalaglawcenter.org/wp-content/uploads/assets/crs/R44114.pdf.Ulloa M, Fernández A, Ariyama N, Colom-Rivero A, Rivera C, Nuñez P, et al. Mass mortality event in South American Sea Lions (Otaria flavescens) correlated to highly pathogenic avian influenza (Hpai) H5N1 outbreak in Chile. Veterinary Quarterly. 2023;43(1):1–10. doi:10.1080/01652176.2023.2265173Ulloa M, Fernández A, Ariyama N, Colom-Rivero A, Rivera C, Nuñez P, et al. Mass mortality event in South American Sea Lions (Otaria flavescens) correlated to highly pathogenic avian influenza (Hpai) H5N1 outbreak in Chile. Veterinary Quarterly. 2023;43(1):1–10. doi:10.1080/01652176.2023.2265173First confirmed cases of Avian Influenza in the Antarctic regionURL: https://www.bas.ac.uk/media-post/first-confirmed-cases-of-avian-influenza-in-the-antarctic-region/First confirmed cases of Avian Influenza in the Antarctic regionURL: https://www.bas.ac.uk/media-post/first-confirmed-cases-of-avian-influenza-in-the-antarctic-region/Avian influenza overview June–September 2023. URL: https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2023.8328Avian influenza overview June–September 2023. URL: https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2023.8328Xie R, Edwards KM, Wille M, Wei X, Wong S-S, Zanin M, et al. The episodic resurgence of highly pathogenic avian influenza H5 virus. Nature. 2023;622(7984):810–7. doi:10.1038/s41586-023-06631-2Xie R, Edwards KM, Wille M, Wei X, Wong S-S, Zanin M, et al. The episodic resurgence of highly pathogenic avian influenza H5 virus. Nature. 2023;622(7984):810–7. doi:10.1038/s41586-023-06631-2Электронный ресурс Всемирной продовольственной организации. URL: https://www.fao.org/animal-health/situation-updates/global-aiv-with-zoonotic-potential/bird-speciesaffected-by-h5nx-hpai/en,Электронный ресурс Всемирной продовольственной организации. URL: https://www.fao.org/animal-health/situation-updates/global-aiv-with-zoonotic-potential/birdspecies-affected-by-h5nx-hpai/en,Domańska-Blicharz K, Świętoń E, Świątalska A, Monne I, Fusaro A, Tarasiuk K, et al. Outbreak of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4B virus in cats, Poland, June to July 2023. Eurosurveillance. 2023;28(31). doi:10.2807/1560-7917.es.2023.28.31.2300366Domańska-Blicharz K, Świętoń E, Świątalska A, Monne I, Fusaro A, Tarasiuk K, et al. Outbreak of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4B virus in cats, Poland, June to July 2023. Eurosurveillance. 2023;28(31). doi:10.2807/1560-7917.es.2023.28.31.2300366Cumulative number of confirmed human cases for avian influenza A(H5N1) reported to WHO, 2003-2023, 3 October 2023. URL: https://www.who.int/publications/m/item/cumulative-number-of-confirmed-human-cases-for-avian-influenzaa(h5n1)-reported-to-who--2003-2023--3-october-2023/Cumulative number of confirmed human cases for avian influenza A(H5N1) reported to WHO, 2003-2023, 3 October 2023. URL: https://www.who.int/publications/m/item/cumulative-number-of-confirmed-human-cases-for-avian-influenzaa(h5n1)-reported-to-who--2003-2023--3-october-2023/Le MQ, Horby P, Fox A, Nguyen HT, Le Nguyen HK, Hoang PM, et al. Subclinical avian influenza A(H5N1) virus infection in human, Vietnam. Emerging Infectious Diseases. 2013;19(10):1674–7. doi:10.3201/eid1910.130730Le MQ, Horby P, Fox A, Nguyen HT, Le Nguyen HK, Hoang PM, et al. Subclinical avian influenza A(H5N1) virus infection in human, Vietnam. Emerging Infectious Diseases. 2013;19(10):1674–7. doi:10.3201/eid1910.130730Ungchusak K, Auewarakul P, Dowell SF, Kitphati R, Auwanit W, Puthavathana P, et al. Probable person-to-person transmission of avian influenza A (H5N1). New England Journal of Medicine. 2005;352(4):333–40. doi:10.1056/nejmoa044021Ungchusak K, Auewarakul P, Dowell SF, Kitphati R, Auwanit W, Puthavathana P, et al. Probable person-to-person transmission of avian influenza A (H5N1). New England Journal of Medicine. 2005;352(4):333–40. doi:10.1056/nejmoa044021Yu H, Shu Y, Hu S, Zhang H, Gao Z, Chen H, et al. The first confirmed human case of avian influenza A (H5N1) in mainland China. The Lancet. 2006;367(9504):84. doi:10.1016/s0140-6736(05)67894-4Yu H, Shu Y, Hu S, Zhang H, Gao Z, Chen H, et al. The first confirmed human case of avian influenza A (H5N1) in mainland China. The Lancet. 2006;367(9504):84. doi:10.1016/s0140-6736(05)67894-4Yu H, Gao Z, Feng Z, Shu Y, Xiang N, Zhou L, et al. Clinical characteristics of 26 human cases of highly pathogenic avian influenza A (H5N1) virus infection in China. PLoS ONE. 2008;3(8). doi:10.1371/journal.pone.0002985Yu H, Gao Z, Feng Z, Shu Y, Xiang N, Zhou L, et al. Clinical characteristics of 26 human cases of highly pathogenic avian influenza A (H5N1) virus infection in China. PLoS ONE. 2008;3(8). doi:10.1371/journal.pone.0002985Shu Y, Yu H, Li D. Lethal avian influenza A (H5N1) infection in a pregnant woman in Anhui Province, China. New England Journal of Medicine. 2006;354(13):1421–2. doi:10.1056/nejmc053524Shu Y, Yu H, Li D. Lethal avian influenza A (H5N1) infection in a pregnant woman in Anhui Province, China. New England Journal of Medicine. 2006;354(13):1421–2. doi:10.1056/nejmc053524URL: https://www.un.org/ru/documents/decl_conv/conventions/pdf/health_regulations.pdfURL: https://www.un.org/ru/documents/decl_conv/conventions/pdf/health_regulations.pdfBertran K, Balzli C, Lee D-H, Suarez DL, Kapczynski DR, Swayne DE. Protection of White Leghorn chickens by U.S. emergency H5 vaccination against clade 2.3.4.4 H5N2 high pathogenicity avian influenza virus. Vaccine. 2017;35(46):6336–44. doi:10.1016/j.vaccine.2017.05.051Bertran K, Balzli C, Lee D-H, Suarez DL, Kapczynski DR, Swayne DE. Protection of White Leghorn chickens by U.S. emergency H5 vaccination against clade 2.3.4.4 H5N2 high pathogenicity avian influenza virus. Vaccine. 2017;35(46):6336–44. doi:10.1016/j.vaccine.2017.05.051High pathogenicity avian influenza and vaccination: application in Europe Region. URL: https://www.woah.org/app/uploads/2023/03/2022-eur2-brown-3335-a.pdfHigh pathogenicity avian influenza and vaccination: application in Europe Region. URL: https://www.woah.org/app/uploads/2023/03/2022-eur2-brown-3335-a.pdfShi J, Zeng X, Cui P, Yan C, Chen H. Alarming situation of emerging H5 and H7 avian influenza and effective control strategies. Emerging Microbes & Infections. 2022;12(1). doi: 10.1080/22221751.2022.2155072Shi J, Zeng X, Cui P, Yan C, Chen H. Alarming situation of emerging H5 and H7 avian influenza and effective control strategies. Emerging Microbes & Infections. 2022;12(1). doi: 10.1080/22221751.2022.2155072

The authors declare that there are no conflicts of interest present.