jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2023-15-3-29-38jofin-1538Research ArticleОбзорReviewЛабораторные маркёры полиорганной патологии при тяжёлом течении и неблагоприятных исходах инфекции SARS-CoV-2 (систематический обзор литературы)Laboratory markers of multiple organ pathology in severe cases and adverse outcomes of SARS-CoV-2 infection (systematic review)КонышкоН. А.KonyshkoN. A.

Конышко Наталья Александровна – доцент кафедры общей врачебной практики ИПО ПМГМУ им. И.М. Сеченова, доктор медицинских наук.

Москва

тел.: +7-951-694-60-64

Moscow

Nkonyshko@yandex.ruВолынецЛ. И.VolynetsL. I.

Волынец Лариса Исаковна – главный врач Смоленской ОКБ, кандидат медицинских наук.

Смоленск

тел.: 8(4812) 55-40-76

Smolensk

smolokb@yandex.ruКонышкоГ. С.KonyshkoG. S.

Конышко Григорий Сергеевич – студент 2 курса стоматологического факультета.

Смоленск

тел.: +7-951-694-73-41

Smolensk

Nkonyshko@yandex.ruПервый Московский государственный медицинский университет им. И.М. СеченоваРоссияFirst Moscow State Medical University named after I.M. SechenovRussian FederationСмоленская областная клиническая больницаРоссияSmolensk Regional Clinical HospitalRussian FederationСмоленский государственный медицинский университетРоссияSmolensk State Medical UniversityRussian Federation2023121020231532938Copyright © Конышко Н.А., Волынец Л.И., Конышко Г.С., 20232023Конышко Н.А., Волынец Л.И., Конышко Г.С.Konyshko N.A., Volynets L.I., Konyshko G.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1538

Представлены современные научно обоснованные сведения о лабораторных параметрах пациентов с тяжёлым течением и неблагоприятными исходами инфекции SARS-CoV-2. Проанализированы полнотекстовые публикации клинических, рандомизированных и когортных исследований, систематические обзоры и мета-анализы из научных баз PubMed, Elsevier, Scopus, Google Scholar, E-library за период с 2019 по 2022 г. Определены конкретные биомаркеры, включая воспалительные и иммунологические параметры (C-реактивный белок, прокальцитонин, интерлейкин-6, D-димер, ферритин), гематологические (количество нейтрофилов, лимфоцитов, их соотношение, RDW), миокардиальные (тропонин, креатинкиназа, миоглобин), печеночные (АСТ, АЛТ, общий билирубин, альбумин) и характеризующие повреждение легких (гликопротеин Кребса фон ден Лунгена-6), которые могут быть использованы для стратификации риска, в качестве прогностических критериев неблагоприятного течения заболевания, в том числе полиорганной недостаточности, тяжёлого  течения и летального исхода пациентов с COVID-19. В исследованиях продемонстрирована роль новых биомаркеров воспалительных и системных проявлений COVID-19: прокальцитонина, кальпротектина и пресепсина.

The aim of the review: to present up-to-date scientifically based information about the laboratory parameters of patients associated with severe SARS-CoV-2 infection and internal organ damage. Materials and methods: full-text publications of clinical, randomized and cohort studies, systematic reviews and meta-analyses from scientific databases PubMed, Elsevier, Scopus, Google Scholar, E-library for the period from 2019 to 2022 were analyzed. Results. Specific biomarkers were identified, including inflammatory and immunological parameters (C-reactive protein, procalcitonin, IL6), hematological (number of lymphocytes and neutrophils, NLR, D-dimer, ferritin, RDW), myocardial (troponin, creatinekinase-MB, myoglobin), hepatic (AST, ALT, total bilirubin, albumin) and characterizing lung injury (KL-6), which can be used for risk stratification, as prognostic biomarkers of adverse clinical consequences, including death in patients with COVID-19. The studies demonstrated new biomarkers of inflammatory and systemic manifestations of COVID19: procalcitonin, calprotectin and presepsin.

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The authors declare that there are no conflicts of interest present.