jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2023-15-1-5-15jofin-1465Research ArticleОбзорReviewВакцинация как стратегия преодоления антимикробной резистентности: свежий взгляд на известную проблемуVaccination as a strategy to overcome antimicrobial resistance: a fresh look on a well-known problemСтомаИ. О.StomaI. O.

Стома Игорь Олегович – ректор, профессор кафедры инфекционных болезней, д.м.н., профессор

Гомель

Gomel

rektor@gsmu.byГомельский государственный медицинский университетБеларусьGomel state medical universityBelarus202318042023151515Copyright © Стома И.О., 20232023Стома И.О.Stoma I.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1465

Вопрос антимикробной резистентности продолжает оставаться на первой странице повестки мировых проблем. Система факторов, влияющих на рост резистентности бактерий к антибиотикам, формируется на основе нескольких направлений (медицина, ветеринария, сельское хозяйство и окружающая среда). Соответственно, и решение проблемы антимикробной резистентности требует понимания концепции единого здоровья (One Health approach). Вакцинация как важнейший инструмент борьбы с антимикробной резистентностью подробно рассмотрена в настоящем обзоре. Представлены вакцин-индуцированные прямые и косвенные механизмы преодоления антимикробной резистентности, а также обозначены современная доказательная база и перспективы расширения применения вакцин в контексте данной проблемы.  

Более массовая вакцинация как против известных бактериальных патогенов (пневмококк, гемофильная инфекция типа b, брюшной тиф), так и против вирусных инфекций (грипп, ротавирусная инфекция) позволит снизить бремя резистентных к антибиотикам инфекций и таким образом сохранить эффективные опции для лечения и спасения человеческих жизней. 

The issue of antimicrobial resistance continues to be on the first page of the global agenda. The system of factors influencing the growth of antibiotic resistance in bacteria comes from various fields (medicine, veterinary medicine, agriculture and the environment), what requires a One Health approach. Vaccination as one of the most important tools against antimicrobial resistance is considered in detail in this review. Vaccine-induced direct and indirect mechanisms for overcoming antimicrobial resistance are presented, as well as the current evidence base and perspectives for expanding the use of vaccines in the context of this problem. Increased vaccination against both known bacterial pathogens (Pneumococcus, Haemophilus influenza type b, typhoid fever) and viral infections (influenza, rotavirus) would reduce the burden of antibiotic-resistant infections, and thus preserve effective options for treatment and saving lives. 

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The authors declare that there are no conflicts of interest present.