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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jofin</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал инфектологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Infectology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-6732</issn><publisher><publisher-name>IPO “АIDSSPbR"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22625/2072-6732-2022-14-3-45-49</article-id><article-id custom-type="elpub" pub-id-type="custom">jofin-1396</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальное исследование</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Развитие спонтанных межмышечных кровотечений  у пациентов с новой коронавирусной инфекцией в инфекционном стационаре</article-title><trans-title-group xml:lang="en"><trans-title>The development of spontaneous intermuscular bleeding in patients with a new coronavirus infection in an infectious disease hospital</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Несвит</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Nesvit</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Несвит Евгения Михайловна – врач-хирург хирургического отделения.</p><p>Санкт-Петербург, тел.: +7-911-709-16-49</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">evgenianesvit@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Медведев</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Medvedev</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Медведев Константин Валерьевич – главный хирург Клинической инфекционной больницы  им. С.П. Боткина, доцент кафедры факультетской хирургии им. профессора А.А. Русанова  Санкт-Петербургского ГПМУ, кандидат медицинских наук</p><p>Санкт-Петербург; тел.: +7-921-993-92-58</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">meddoc76@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ерофеев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Erofeev</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ерофеев Александр Алексеевич – заместитель главного врача по хирургии, кандидат медицинских наук.</p><p>Санкт-Петербург; тел.: +7-921-955-04-58</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">aerofeev1963@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Протченков</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Protchenkov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Протченков Михаил Александрович – доцент кафедры факультетской хирургии им. профессора А.А. Русанова Санкт-Петербургского ГПМУ, заместитель главного врача по хирургии Городской больницы № 26, доктор медицинских наук.</p><p>Санкт-Петербург; тел.: +7-911-913-67-98</p></bio><bio xml:lang="en"><p>Saint-Petersburg</p></bio><email xlink:type="simple">cooperit@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Клиническая инфекционная больница им. С.П. Боткина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinical Infectious Hospital named after S.P. Botkin</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Клиническая инфекционная больница им. С.П. Боткина; Санкт-Петербургский государственный педиатрический медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinical Infectious Hospital named after S.P. Botkin; Saint-Petersburg State Pediatric Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Городская многопрофильная больница № 2</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Hospital № 2</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Санкт-Петербургский государственный педиатрический медицинский университет; Городская многопрофильная больница № 26</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint-Petersburg State Pediatric Medical University; City Hospital № 26</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>21</day><month>10</month><year>2022</year></pub-date><volume>14</volume><issue>3</issue><issue-title>спецвыпуск</issue-title><fpage>45</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Несвит Е.М., Медведев К.В., Ерофеев А.А., Протченков М.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Несвит Е.М., Медведев К.В., Ерофеев А.А., Протченков М.А.</copyright-holder><copyright-holder xml:lang="en">Nesvit E.M., Medvedev K.V., Erofeev A.A., Protchenkov M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.niidi.ru/jofin/article/view/1396">https://journal.niidi.ru/jofin/article/view/1396</self-uri><abstract><p>На сегодняшний день новая коронавирусная инфекция остается одной из самых актуальных проблем современной медицины. У пациентов, требующих стационарного лечения, достаточно часто имеет место развитие различных внелегочных осложнений. Работа посвящена исследованию спонтанных гематом различной локализации на фоне тяжелого течения новой коронавирусной инфекции, проходивших лечение в условиях инфекционного стационара в период 2020– 2021 гг. За этот период у 17 пациентов отмечались появление спонтанных гематом различных локализаций (передняя брюшная стенка, забрюшинное пространство, шея, бедро, грудная клетка). Исследована эффективность инструментальной диагностики, в качестве оптимального метода признана компьютерная томография в сосудистом режиме, помогающая идентифицировать не только расположение гематомы, но и в ряде случаев ее источник. Описаны основные принципы тактики выбора методов гемостаза (медикаментозный, механический, хирургический) для достижения его стойкой эффективности.</p></abstract><trans-abstract xml:lang="en"><p>Today the new coronavirus infection remains one of the most important problems of modern medicine. Among patients requiring hospital treatment, the development of various extrapulmonary complications is quite common. The work is devoted to the study of spontaneous hematomas of various localization against the background of a severe course of a new coronavirus infection treated in an infectious hospital in the period from 2020 to 2021. During the selected time, 17 patients had spontaneous hematomas of various localizations (anterior abdominal wall, retroperitoneal space, neck, hip, chest). The paper investigates the effectiveness of instrumental diagnostics – computed tomography in vascular mode is recognized as the optimal method, which helps to identify not only the location of the hematoma, but also in some cases its source. The basic principles of the tactics of choosing methods of hemostasis (medical, mechanical, surgical) to achieve its sustained effectiveness are described.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>новая коронавирусная инфекция</kwd><kwd>спонтанные гематомы</kwd><kwd>гемостаз</kwd><kwd>коагулопатии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>new coronavirus infection</kwd><kwd>spontaneous hematomas</kwd><kwd>hemostasis</kwd><kwd>coagulopathy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Iba, T. Coagulopathy in COVID-19 / T. Iba, J.H. Levy, M. Levi [et al.] // J. Thromb. Haemost. / – 2020. – V. 18. – №9. – P. 2103–2109.</mixed-citation><mixed-citation xml:lang="en">Iba, T. Coagulopathy in COVID-19 / T. Iba, J.H. Levy, M. Levi [et al.] // J. Thromb. Haemost. / – 2020. – V. 18. – №9. – P. 2103–2109.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hadid, T. Coagulation and anticoagulation in COVID-19 / T. Hadid, Z. Kafri, A. Al-Katib. // Blood Rev. – 2021. – V. 47. – P. 100761</mixed-citation><mixed-citation xml:lang="en">Hadid, T. Coagulation and anticoagulation in COVID-19 / T. Hadid, Z. Kafri, A. Al-Katib. // Blood Rev. – 2021. – V. 47. – P. 100761</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Levi, M. Coagulation abnormalities and thrombosis in patients with COVID-19 / M. Levi, J. Thachil, T. Iba [et al.] // Lancet Haematol. – 2020. – V. 7. – №6. – P. 438–440.</mixed-citation><mixed-citation xml:lang="en">Levi, M. Coagulation abnormalities and thrombosis in patients with COVID-19 / M. Levi, J. Thachil, T. Iba [et al.] // Lancet Haematol. – 2020. – V. 7. – №6. – P. 438–440.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Marietta, M. COVID-19, coagulopathy and venous thromboembolism: more questions than answers. / M. Marietta, V. Coluccio, M. Luppi. // Intern. Emerg. Med. – 2020. – V.15. – №8. – P. 1375–1387.</mixed-citation><mixed-citation xml:lang="en">Marietta, M. COVID-19, coagulopathy and venous thromboembolism: more questions than answers. / M. Marietta, V. Coluccio, M. Luppi. // Intern. Emerg. Med. – 2020. – V.15. – №8. – P. 1375–1387.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lippi, G. Coronavirus disease 2019-associated coagulopathy. / G. Lippi, F. Sanchis-Gomar, E.J. Favaloro [et al.]. // Mayo Clin. Proc. – 2021/ – V. 96. – №1. – P. 203–217.</mixed-citation><mixed-citation xml:lang="en">Lippi, G. Coronavirus disease 2019-associated coagulopathy. / G. Lippi, F. Sanchis-Gomar, E.J. Favaloro [et al.]. // Mayo Clin. Proc. – 2021/ – V. 96. – №1. – P. 203–217.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Henry, B.M. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. / B.M. Henry, M.H.S. de Oliveira, S. Benoit [et al.]. // Clin. Chem. Lab. Med. – 2020. – V. 58. – №7. – P. 1021–1028.</mixed-citation><mixed-citation xml:lang="en">Henry, B.M. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. / B.M. Henry, M.H.S. de Oliveira, S. Benoit [et al.]. // Clin. Chem. Lab. Med. – 2020. – V. 58. – №7. – P. 1021–1028.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lippi, G. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. / G. Lippi, M. Plebani, B.M. Henry. // Clin. Chim. Acta. – 2020. – №506. – P. 145–148.</mixed-citation><mixed-citation xml:lang="en">Lippi, G. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. / G. Lippi, M. Plebani, B.M. Henry. // Clin. Chim. Acta. – 2020. – №506. – P. 145–148.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lippi, G. D-dimer is associated with severity of coronavirus disease 2019: a pooled analysis. / G. Lippi, E.J. Favaloro. // Thromb. Haemost. – 2020. – V. 120. – №5.- P. 876–878.</mixed-citation><mixed-citation xml:lang="en">Lippi, G. D-dimer is associated with severity of coronavirus disease 2019: a pooled analysis. / G. Lippi, E.J. Favaloro. // Thromb. Haemost. – 2020. – V. 120. – №5.- P. 876–878.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Guan, W.J. Clinical Characteristics of Coronavirus Disease 2019 in China. / W.J. Guan, Z.Y. Ni, Y/ Hu [et al]. – N. Engl. J. Med. – 2020. – V. 382. – №18. – P. 1708-1720. [Doi:10.1056/NEJMoa2002032].</mixed-citation><mixed-citation xml:lang="en">Guan, W.J. Clinical Characteristics of Coronavirus Disease 2019 in China. / W.J. Guan, Z.Y. Ni, Y/ Hu [et al]. – N. Engl. J. Med. – 2020. – V. 382. – №18. – P. 1708-1720. [Doi:10.1056/NEJMoa2002032].</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou, F. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. / F. Zhou, T. Yu, R. Du [et al.]/ – Lancet. – 2020. – V. 395. – №10229. – P. 1054-1062.</mixed-citation><mixed-citation xml:lang="en">Zhou, F. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. / F. Zhou, T. Yu, R. Du [et al.]/ – Lancet. – 2020. – V. 395. – №10229. – P. 1054-1062.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Fox, S.E. Pulmonary and Cardiac Pathology in Covid-19: The First Autopsy Series from New Orleans. / S.E. Fox, A. Akmatbekov, J.L. Harbert [et al]. // Preprint. – 2020. – V. 8. -№7. – P. 681-686. [Doi:10.1016/S2213-2600(20)30243-5].</mixed-citation><mixed-citation xml:lang="en">Fox, S.E. Pulmonary and Cardiac Pathology in Covid-19: The First Autopsy Series from New Orleans. / S.E. Fox, A. Akmatbekov, J.L. Harbert [et al]. // Preprint. – 2020. – V. 8. -№7. – P. 681-686. [Doi:10.1016/S2213-2600(20)30243-5].</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Tang, N. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. // N. Tang, D. Li, X. Wang [et al]. // J. Thromb. Haemost. – 2020. – V. 18. – №4. – P. 844-847.</mixed-citation><mixed-citation xml:lang="en">Tang, N. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. // N. Tang, D. Li, X. Wang [et al]. // J. Thromb. Haemost. – 2020. – V. 18. – №4. – P. 844-847.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Malas, M.B. Thromboembolism risk of COVID-19 is high and associated with a higher risk of mortality: a systematic review and meta-analysis. / M.B. Malas,. I.N. Naazie, N. Elsayed [et al]. // E. Clinical. Medicine. – V. 2020. – V. 9. – P. 100639.</mixed-citation><mixed-citation xml:lang="en">Malas, M.B. Thromboembolism risk of COVID-19 is high and associated with a higher risk of mortality: a systematic review and meta-analysis. / M.B. Malas,. I.N. Naazie, N. Elsayed [et al]. // E. Clinical. Medicine. – V. 2020. – V. 9. – P. 100639.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Cui, S. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. / S. Cui, S. Chen, X. Li, // J. Thromb. Haemost. // 2020. – V. 18. – №6. – P. 1421-1424. [Doi:10.1111/jth.14830].</mixed-citation><mixed-citation xml:lang="en">Cui, S. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. / S. Cui, S. Chen, X. Li, // J. Thromb. Haemost. // 2020. – V. 18. – №6. – P. 1421-1424. [Doi:10.1111/jth.14830].</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Samkari, H. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. / H. Al-Samkari, R.S. Karp Leaf, W.H. Dzik [et al]. // Blood. – 2020. – V. 136. – P. 489–500.</mixed-citation><mixed-citation xml:lang="en">Al-Samkari, H. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. / H. Al-Samkari, R.S. Karp Leaf, W.H. Dzik [et al]. // Blood. – 2020. – V. 136. – P. 489–500.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gomez, K. Debate: should the dose or duration of anticoagulants for the prevention of venous thrombosis be increased in patients with COVID-19 while we are awaiting the results of clinical trials? / K. Gomez, M. Laffan, C. Bradburry [et al]. // Br. J. Haematol. – 2021. – V. 192. – P. 459–66.</mixed-citation><mixed-citation xml:lang="en">Gomez, K. Debate: should the dose or duration of anticoagulants for the prevention of venous thrombosis be increased in patients with COVID-19 while we are awaiting the results of clinical trials? / K. Gomez, M. Laffan, C. Bradburry [et al]. // Br. J. Haematol. – 2021. – V. 192. – P. 459–66.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Spyropoulos, A.C. Subcommittee on Perioperative, Critical Care Thrombosis, Haemostasis of the Scientific, Standardization Committee of the International Society on Thrombosis and Haemostasis. Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19. / A.C. Spyropoulos, J.H. Levy, W. Ageno [et al.]. // J. Thromb. Haemost. – 2020. –V. 18. – №8. – P. 1859–1865.</mixed-citation><mixed-citation xml:lang="en">Spyropoulos, A.C. Subcommittee on Perioperative, Critical Care Thrombosis, Haemostasis of the Scientific, Standardization Committee of the International Society on Thrombosis and Haemostasis. Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19. / A.C. Spyropoulos, J.H. Levy, W. Ageno [et al.]. // J. Thromb. Haemost. – 2020. –V. 18. – №8. – P. 1859–1865.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Rogani, S. Spontaneous muscle hematoma in older patients with COVID-19: two case reports and literature review. / S. Rogani, V. Calsolaro, R. Franchi [et al.]. – BMC Geriatr. – 2020. – V. 20. – №1. – P.539</mixed-citation><mixed-citation xml:lang="en">Rogani, S. Spontaneous muscle hematoma in older patients with COVID-19: two case reports and literature review. / S. Rogani, V. Calsolaro, R. Franchi [et al.]. – BMC Geriatr. – 2020. – V. 20. – №1. – P.539</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
