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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jofin</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал инфектологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Infectology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-6732</issn><publisher><publisher-name>IPO “АIDSSPbR"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22625/2072-6732-2022-14-4-118-125</article-id><article-id custom-type="elpub" pub-id-type="custom">jofin-1388</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клинический случай</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Case</subject></subj-group></article-categories><title-group><article-title>Врожденная цитомегаловирусная инфекция: особенности клинического течения и катамнез по данным собственного наблюдения</article-title><trans-title-group xml:lang="en"><trans-title>Congenital cytomegalovirus infection: features of the clinical course and catamnesis according to own observations</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анциферова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Antsiferova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анциферова Екатерина Владимировна – доцент кафедры педиатрии института последипломного образования, врач-неонатолог отделения патологии новорожденных и недоношенных детей (II этап), к.м.н.; тел.:: 8(391)243-39-52, 8(391)222-02-73</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Krasnoyarsk</p></bio><email xlink:type="simple">anciferova_ekate@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таранушенко</surname><given-names>Т. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Taranushenko</surname><given-names>T. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Таранушенко Татьяна Евгеньевна – заведующая кафедрой педиатрии института последипломного образования, д.м.н., профессор; тел.: 8(391)243-39-52</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Krasnoyarsk</p></bio><email xlink:type="simple">tetar@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Генинова</surname><given-names>Д. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Geninova</surname><given-names>D. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Генинова Дарима Гэндэновна – врач-неонатолог отделения патологии новорожденных и недоношенных детей (II этап); тел.: 8(391) 222-02-73</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Krasnoyarsk</p></bio><email xlink:type="simple">darima_geninova@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпова</surname><given-names>Л. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpova</surname><given-names>L. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпова Людмила Николаевна – ассистент кафедры педиатрии института последипломного образования, заместитель главного врача по медицинской части (неонатология), к.м.н.; тел.: 8(391)243-39-52, 8(391)222-02-73</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Krasnoyarsk</p></bio><email xlink:type="simple">lu68@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филиппова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Filippova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Филиппова Лилия Анатольевна – врач функциональной диагностики, врач – детский кардиолог отделения патологии новорожденных и недоношенных детей (II этап); тел.: 8(391)222-02-73</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Krasnoyarsk</p></bio><email xlink:type="simple">filippova.lili@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Караганова</surname><given-names>К. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Karaganova</surname><given-names>K. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Караганова Ксения Игоревна – врач акушер-гинеколог консультативной поликлиники перинатального центра; тел.: 8(391)222-02-66</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Krasnoyarsk</p></bio><email xlink:type="simple">karaganova2207@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpova</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпова Лика Сергеевна – студент педиатрического факультета; тел.: 8(391)228-08-76</p><p>Красноярск</p></bio><bio xml:lang="en"><p>Krasnoyarsk</p></bio><email xlink:type="simple">likins_cool@bk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Красноярский государственный медицинский университет им. профессора В.Ф. Войно-Ясенецкого; Красноярский краевой клинический центр охраны материнства и детства</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky; Krasnoyarsk Regional Clinical Center for Maternity and Childhood Protection</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Красноярский государственный медицинский университет им. профессора В.Ф. Войно-Ясенецкого</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Красноярский краевой клинический центр охраны материнства и детства</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Krasnoyarsk Regional Clinical Center for Maternity and Childhood Protection</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>19</day><month>10</month><year>2022</year></pub-date><volume>14</volume><issue>4</issue><fpage>118</fpage><lpage>125</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Анциферова Е.В., Таранушенко Т.Е., Генинова Д.Г., Карпова Л.Н., Филиппова Л.А., Караганова К.И., Карпова Л.С., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Анциферова Е.В., Таранушенко Т.Е., Генинова Д.Г., Карпова Л.Н., Филиппова Л.А., Караганова К.И., Карпова Л.С.</copyright-holder><copyright-holder xml:lang="en">Antsiferova E.V., Taranushenko T.E., Geninova D.G., Karpova L.N., Filippova L.A., Karaganova K.I., Karpova L.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.niidi.ru/jofin/article/view/1388">https://journal.niidi.ru/jofin/article/view/1388</self-uri><abstract><p>Врожденная цитомегаловирусная инфекция является наиболее распространенной врожденной инфекцией, встречается у 0,6–5% новорожденных детей во всем мире и считается ведущей негенетической причиной нейросенсорной тугоухости у детей. У большей части новорожденных с манифестной формой заболевания развиваются психомоторные и когнитивные расстройства, примерно половина имеют нарушения зрения.</p><sec><title>Цель</title><p>Цель: представить клинический случай тяжелой врожденной цитомегаловирусной инфекции в период манифестации с полисистемными проявлениями (геморрагический синдром, энцефалит, миокардит, гепатит, спленомегалия) и данные катамнеза в возрасте 1 года.</p></sec><sec><title>Заключение</title><p>Заключение: данный клинический пример демонстрирует диагностические и лечебные сложности в остром периоде болезни и значительный перечень заболеваний, явившихся последствиями перенесенной инфекции. На основании представленных сведений актуализируется важность и необходимость пристального внимания к результатам серологического исследования беременных в течение всего срока гестации с оценкой титра антител к цитомегаловирусной инфекции в динамике. Специфическая противовирусная терапия, назначенная на основании жизнеугрожающего течения тяжелой манифестной формы заболевания, позволила достигнуть положительной динамики в острый период, эрадицировать вирус и не допустить тяжелых исходов, в том числе летальности.</p></sec></abstract><trans-abstract xml:lang="en"><p>Congenital cytomegalovirus infection is the most common congenital infection, occurs in 0.6-5% of newborns worldwide, and is considered the leading non-genetic cause of sensorineural hearing loss in children. Most newborns with a manifest form of the disease develop psychomotor and cognitive disorders, and about half of them develop visual impairment.</p><p>The purpose of publication: to present a clinical case of severe congenital cytomegalovirus infection in the manifest period with multisystem manifestations (hemorrhagic syndrome, encephalitis, myocarditis, hepatitis, splenomegaly) and follow-up data at the age of 1 year.</p><p>Conclusion. this clinical example demonstrates diagnostic and therapeutic difficulties in the acute period of the disease and a significant list of diseases resulting from infection. Based on the information presented, the importance and necessity of close attention to the results of a serological study of pregnant women during the entire gestation period with an assessment of the antibody titer to cytomegalovirus infection in dynamics are updated. Specific antiviral therapy, prescribed on the basis of a life-threatening course of a severe manifest form of the disease, made it possible to achieve positive dynamics in the acute period, eradicate the virus and prevent severe outcomes, including death.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>цитомегаловирусная инфекция</kwd><kwd>новорожденный</kwd><kwd>тромбоцитопения</kwd><kwd>гепатит</kwd><kwd>миокардит</kwd><kwd>задержка внутриутробного развития</kwd><kwd>ганцикловир</kwd><kwd>валганцикловир</kwd><kwd>нейросенсорная тугоухость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cytomegalovirus infection</kwd><kwd>newborn</kwd><kwd>thrombocytopenia</kwd><kwd>hepatitis</kwd><kwd>myocarditis</kwd><kwd>intrauterine growth retardation</kwd><kwd>ganciclovir</kwd><kwd>valganciclovir</kwd><kwd>sensorineural hearing loss</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Marsico C, Kimberlin DW. 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