jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2022-14-2-55-64jofin-1353Research ArticleОбзорReviewКлинико-этиологические аспекты бета-герпес-вирусной инфекции человека 6: обзор литературыClinical and etiological aspects of human Betaherpesvirus infection 6: a reviewТянН. С.TianN. S.

Тян Наталья Сергеевна – младший научный сотрудник научно-исследовательского отдела капельных инфекций; тел.: 8(812)234-29-87, +7-952-387-18-62

Санкт-Петербург

Saint-Petersburg

tiannatalia94@yandex.ruГолеваО. В.GolevaO. V.

Голева Ольга Владимировна – старший научный сотрудник научно-исследовательского отдела экспериментальной медицинской вирусологии, молекулярной генетики и биобанкинга; к.б.н.; тел.: 8(812) 234-07-40, +7-921-649-05-63

Санкт-Петербург

Saint-Petersburg

golev.ao@mail.ruБабаченкоИ. В.BabachenkoI. V.

Бабаченко Ирина Владимировна – заведующий научно-исследовательским отделом капельных инфекций; профессор кафедры инфекционных заболеваний у детей ФП и ДПО; д.м.н., профессор; тел.: 8(812) 234-29-87, +7-921-579-96-51

Санкт-Петербург

Saint-Petersburg

babachenko-doc@mail.ruДетский научно-клинический центр инфекционных болезнейРоссияPediatric Research and Clinical Center for Infectious DiseasesRussian FederationДетский научно-клинический центр инфекционных болезней; Санкт-Петербургский государственный педиатрический медицинский университетРоссияPediatric Research and Clinical Center for Infectious Diseases; Saint-Petersburg State Pediatric Medical UniversityRussian Federation2022130720221425564Copyright © Тян Н.С., Голева О.В., Бабаченко И.В., 20222022Тян Н.С., Голева О.В., Бабаченко И.В.Tian N.S., Goleva O.V., Babachenko I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1353

Литературный обзор посвящен современному представлению о бета-герпес-вирусах человека 6 (вирус герпеса человека 6; ВГЧ-6). Проведен анализ литературы преимущественно за последние 5 лет. В статье дана краткая справка об истории открытия вирусов, освещены вопросы таксономии ВГЧ-6, новые взгляды на этиологические особенности вирусов ВГЧ-6А и ВГЧ-6В, в частности, на возможность их генной интеграции. Описаны различия между ВГЧ-6А и В. Представлены современные взгляды на этиологическую связь различных заболеваний центральной и периферической нервной системы, сердца, других органов и систем с ВГЧ-6А и ВГЧ-6В. Отмечены клинические особенности инфекционного мононуклеоза, ассоциированного с ВГЧ-6, а также внезапной экзантемы, наиболее характерной для детей первых 2 лет жизни. Даны современные представления о возможностях и проблемах лабораторной диагностики и лечения ВГЧ-6 инфекции, в том числе у детей. Полученные данные отражают необходимость создания единых протоколов обследования и лечения ВГЧ-6.

The literature review is devoted to the modern concept of human betaherpesvirus 6 (human herpesvirus 6; HHV-6). The analysis of the literature mainly for the last five years was carried out. The article provides a brief background on the history of the discovery of viruses, highlights the taxonomy of HHV-6, new views on the etiological features of the HHV-6A and HHV-6B viruses, in particular, the possibility of their gene integration. Differences between HHV-6A and B are described. Modern views on the etiological relationship of various diseases of the central and peripheral nervous system, а heart, other organs and systems with HHV-6A and HHV-6B are presented. There have been cases of infectious mononucleosis associated with HHV-6, as well as exanthemа subitum that is mostly typical for children under 2 years old. Modern ideas about the possibilities and problems of HHV-6 infection laboratory diagnosis and treatment of children and adult are given. Obtained data points out necessary of a unified protocol creation for the examination and treatment of HHV-6.

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The authors declare that there are no conflicts of interest present.