jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2021-13-3-5-18jofin-1235Research ArticleОбзорReviewСравнительная характеристика бета-герпес-вирусов человека 6А и 6В. Современный взгляд на проблемуComparative characteristics of human betaherpesviruses 6A and 6B. A modern view on the problemПопковаМ. И.PopkovaM. I.

Попкова Мария Игоревна - ведущий научный сотрудник лаборатории молекулярной биологии и биотехнологии, кандидат медицинских наук.

Нижний Новгород.

Тел.: 8(831)469-79-46, +7-906-352-60-15

Nizhny Novgorod.

popmarig@mail.ruУткинО. В.UtkinO. V.

Уткин Олег Владимирович - ведущий научный сотрудник - заведующий лабораторией молекулярной биологии и биотехнологии, кандидат биологических наук.

Нижний Новгород.

Тел.: 8(831)469-79-45

Nizhny Novgorod.

utkino2004@mail.ruБрызгаловаД. А.BryzgalovaD. A.

Брызгалова Дарья Алексеевна - младший научный сотрудник лаборатории молекулярной биологии и биотехнологии.

Нижний Новгород.

Тел.: 8(831)469-79-46

Nizhny Novgorod.

moskvinadara7@gmail.comНижегородский научно-исследовательский институт эпидемиологии и микробиологии им. академика И.Н. БлохинойРоссияNizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology named after Academician I.N. BlokhinaRussian Federation202108102021133518Copyright © Попкова М.И., Уткин О.В., Брызгалова Д.А., 20212021Попкова М.И., Уткин О.В., Брызгалова Д.А.Popkova M.I., Utkin O.V., Bryzgalova D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/1235

Представленный обзор посвящен сравнительной характеристике вируса герпеса человека 6А (ВГЧ6А) и вируса герпеса человека 6В (ВГЧ6В) с учетом их экзогенной и эндогенной (наследуемой хромосомно-интегрированной) форм. Последовательно проведен анализ литературных данных об основных межвидовых различиях и внутривидовых особенностях этих вирусов в молекулярно-генетическом, биологическом, эпидемиологическом и клиническом аспектах. Современные представления о ВГЧ6А и ВГЧ6В, в том числе их уникальной наследуемой хромосомно-интегрированной форме, являются основой для организации системы эпидемиологического надзора за инфекциями, вызываемыми данными вирусами, а также разработки стандартизованных методических подходов к дифференциальной диагностике, лечению и специфической профилактике широкого спектра вирус-ассоциированных заболеваний. Развитие данного направления требует большей доказательной базы и интенсификации совместных усилий научного и врачебного сообществ.

This review is devoted to the comparative characteristics of human herpesvirus 6A (HHV6A) and human herpesvirus 6B (HHV6B), taking into account their exogenous and endogenous (inherited chromosomally integrated) forms. The analysis of the literature data on the main interspecies differences and intraspecies features of these viruses in molecular-genetic, biological, epidemiological and clinical aspects has been consistently carried out. Modern views about HHV6A and HHV6B, including their unique inherited chromosomal-integrated form, are the basis for organizing a system of epidemiological surveillance of infections caused by these viruses, as well as developing standardized methodological approaches to differential diagnosis, treatment and specific prevention of a wide range of virus-associated diseases. The development of this direction requires a greater evidence base and intensification of joint efforts of the scientific and medical communities.

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The authors declare that there are no conflicts of interest present.