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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jofin</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал инфектологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Infectology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-6732</issn><publisher><publisher-name>IPO “АIDSSPbR"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22625/2072-6732-2021-13-1-124-129</article-id><article-id custom-type="elpub" pub-id-type="custom">jofin-1187</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клинический случай</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Case</subject></subj-group></article-categories><title-group><article-title>Синдром «рука-нога-рот», ассоциированный с сочетанной энтеровирусно-стрептококковой инфекцией, у ребенка</article-title><trans-title-group xml:lang="en"><trans-title>Hand, foot and mouth disease associated with streptococcus infection in a child (clinical case)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горишна</surname><given-names>И. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Horishna</surname><given-names>I. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горишна Иванна Любомировна – доцент кафедры педиатрии № 2; детский инфекционист</p><p>Тернопольтел.: +38-097-33-766-15</p></bio><bio xml:lang="en"><p>Ternopil</p></bio><email xlink:type="simple">gorishna_il@tdmu.edu.ua</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Волянская</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Volyanskaya</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Волянская Любовь Августиновна – доцент кафедры детских болезней с детской хирургией; детский инфекционист</p><p>Тернопольтел.: +38-067-10-073-59</p></bio><bio xml:lang="en"><p>Ternopil</p></bio><email xlink:type="simple">volyanska@tdmu.edu.ua</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дывоняк</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dyvonyak</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дывоняк Ольга Николаевна – заведующая инфекционным отделением</p><p>Тернопольтел.: +38-067-73-835-98</p></bio><bio xml:lang="en"><p>Ternopil</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боярчук</surname><given-names>О. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Boyarchuk</surname><given-names>O. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Боярчук Оксана Романовна – заведующая кафедрой детских болезней с детской хирургией; профессор, д.м.н.</p><p>Тернопольтел.: +38-068-62-182-48</p></bio><bio xml:lang="en"><p>Ternopil</p></bio><email xlink:type="simple">boyarchuk@tdmu.edu.ua</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурбела</surname><given-names>Э. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Burbela</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бурбела Эмилия Игоревна – ассистент кафедры детских болезней с детской хирургией</p><p>Тернопольтел.: +38-096-67-353-70</p></bio><bio xml:lang="en"><p>Ternopil</p></bio><email xlink:type="simple">burbelaei@tdmu.edu.ua</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мудрык</surname><given-names>У. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Mudryk</surname><given-names>U. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мудрык Ульяна Михайловна – доцент кафедры детских болезней с детской хирургией; детский инфекционист</p><p>Тернопольтел.: +38-096-44-649-19</p></bio><bio xml:lang="en"><p>Ternopil</p></bio><email xlink:type="simple">mydrukym@tdmu.edu.ua</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тернопольский национальный медицинский университет им. И.Я. Горбачевского</institution><country>Украина</country></aff><aff xml:lang="en"><institution>Ternopil National Medical University named after I.Ya. Horbachevsky</institution><country>Ukraine</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Тернопольская городская детская клиническая больница</institution><country>Украина</country></aff><aff xml:lang="en"><institution>Ternopil City Children’s Clinical Hospital</institution><country>Ukraine</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>29</day><month>03</month><year>2021</year></pub-date><volume>13</volume><issue>1</issue><fpage>124</fpage><lpage>129</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Горишна И.Л., Волянская Л.А., Дывоняк О.Н., Боярчук О.Р., Бурбела Э.И., Мудрык У.М., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Горишна И.Л., Волянская Л.А., Дывоняк О.Н., Боярчук О.Р., Бурбела Э.И., Мудрык У.М.</copyright-holder><copyright-holder xml:lang="en">Horishna I.L., Volyanskaya L.A., Dyvonyak O.N., Boyarchuk O.R., Burbela E.I., Mudryk U.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.niidi.ru/jofin/article/view/1187">https://journal.niidi.ru/jofin/article/view/1187</self-uri><abstract><p>В представленном клиническом случае сочетание двух возбудителей (энтеровируса и стрептококка) обусловило тяжелое и атипичное течение синдрома «рука-нога-рот» у ребенка младшего школьного возраста. Энтеровирусная инфекция, с первых дней заболевания представленная типичной локализацией первичных элементов сыпи и характерным интоксикационным синдромом, подтверждена выявлением РНК энтеровирусов в испражнениях. Течение заболевания было волнообразным. В первую волну высыпания на коже, сопровождавшиеся болезненностью и зудом, соответствовали классической ЭВИ по характеру элементов, их локализации и сочетались с поражением эпителия слизистых оболочек рта. Начиная с 5-х суток заболевания, на фоне усиления выраженности интоксикационного синдрома появились буллезные элементы на коже конечностей, обнаружено превышение допустимых значений антистрептолизина-О в 12 раз, а при посеве материала из трещин угла рта выделен Streptococcus pyogenes 106 КУО, что указывало на сочетание синдрома «рука-нога-рот» со стрептококковой инфекцией. Онихомадезис в периоде реконвалесценции ретроспективно свидетельствовал о доминирующей роли энтеровируса в представленном клиническом случае.</p></abstract><trans-abstract xml:lang="en"><p>In the presented clinical case, the combination of two pathogens (enterovirus and streptococcus) caused a severe and atypical course of the hand-foot-mouth syndrome in a child of primary school age. EVI from the first days of the disease represented by the typical localization of the primary elements of the rash and the characteristic intoxication syndrome was confirmed by the detection of enterovirus RNA in the feces. The course of the disease was undulating. In the first wave, skin rashes accompanied by soreness and itching corresponded to the classical EVI in terms of the nature of the elements, their localization and were combined with lesions of the epithelium of the oral mucosa. Starting from the 5th day of the disease, against the background of an increase in the severity of intoxication syndrome, bullous elements appeared on the skin of the extremities, an excess of the permissible values of antistreptolysin-O was found 12 times, and when sowing material from cracks in the corner of the mouth, Streptococcus pyogenes 106 KUO was isolated, which indicated a combination of the syndrome Hand-foot-mouth with streptococcal infection. Onychomadesis in the period of convalescence retrospectively testified to the dominant role of enterovirus in the presented clinical case.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>энтеровирусная инфекция</kwd><kwd>синдром «рука-нога-рот»</kwd><kwd>стрептококковая инфекция</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Enterovirus infections</kwd><kwd>hand</kwd><kwd>foot</kwd><kwd>and mouth disease</kwd><kwd>streptococcal infection</kwd><kwd>children</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Энтеровирусные инфекции: современные особенности / В. А. Анохин [и др.] // Практическая медицина. 2014. – Т. 85, № 9. – С. 52–59.</mixed-citation><mixed-citation xml:lang="en">Anokhin V.A., Sabitova A.M., Kravchenko I.E., Martynova T.M. Enterovirusni infektsiyi: suchasni osoblyvosti [Enterovirus infections: modern features]. 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