jofinЖурнал инфектологииJournal Infectology2072-6732IPO “АIDSSPbR"10.22625/2072-6732-2012-4-3-80-87jofin-118Research ArticleОригинальные исследованияOriginal ResearchЭЛЕКТРОФИЗИОЛОГИЧЕСКИЕ МЕТОДЫ В ДИАГНОСТИКЕ СУБКЛИНИЧЕСКИХ КОГНИТИВНЫХ НАРУШЕНИЙ У ВИЧ-ИНФИЦИРОВАННЫХ БОЛЬНЫХElectrophysiological methods in the diagnosis of subclinical cognitive impairment in HIV-infected patientsГурскаяО. Е.GurskayaO. E.

заведующий отделением функциональной диагностики Института мозга человека им. Н.П. Бехтеревой РАН, к.м.н.; тел. (812)234-92-44

fdiag-ihb@yandex.ruГаличеваЕ. В.GalichevaE. V.

сотрудник отделения функциональной диагностики Института мозга человека им. Н.П. Бехтеревой РАН, тел. (812)234-92-44

fdiag-ihb@yandex.ruГайсинаА. В.GaisinaA. V.

психолог Санкт-Петербургского центра по профилактике и борьбе со СПИД и инфекционными заболеваниями; тел. (812)407-83-13

aidscentr@zdrav.spb.ruРассохинВ. В.RassohinV. V.

заместитель главного врача по амбулаторно-поликлинической помощи Санкт-Петербургского центра по профилактике и борьбе со СПИД и инфекционными заболеваниями, ведущий научный сотрудник Научно-исследовательского института экспериментальной медицины СЗО РАМН, к.м.н.; тел. (812) 407-83-35

Ras-doc@mail.ruСизоваТ. Д.SizovaT. D.

врач Санкт-Петербургского центра по профилактике и борьбе со СПИД и инфекционными заболеваниями, научный сотрудник Научно-исследовательского института экспериментальной медицины СЗО РАМН; тел. (812)407-83-29

tanja_sizova@list.ruБеляковН. А.BeliakovN. A.

руководитель Санкт-Петербургского центра по профилактике и борьбе со СПИД и инфекционными заболеваниями, главный научный сотрудник Научно-исследовательского института экспериментальной медицины, академик РАМН; тел. (812)251-08-53

aidscentr@zdrav.spb.ruМедведевС. В.MedvedevS. V.

директор Института мозга человека им. Н.П. Бехтеревой РАН, профессор, член-корреспондент РАН; тел. (812)234-13-90

office@ihb.spb.ruИнститут мозга человека им. Н.П. Бехтеревой РАН, Санкт-ПетербургРоссияInstitute of Human Brain named by N.P. Behtereva of Russian Academy of Sciences, Saint-PetersburgRussian FederationСанкт-Петербургский центр по профилактике и борьбе со СПИД и инфекционными заболеваниями, Санкт-ПетербургРоссияSaint-Petersburg Center for the Prevention and Control of AIDS and Infectious Diseases, Saint-PetersburgRussian FederationСанкт-Петербургский центр по профилактике и борьбе со СПИД и инфекционными заболеваниями, Санкт-Петербург Научно-исследовательский институт экспериментальной медицины СЗО РАМН, Санкт-ПетербургРоссияSaint-Petersburg Center for the Prevention and Control of AIDS and Infectious Diseases, Saint-Petersburg Institute of Experimental Medicine Russian Academy of Medical Sciences, Saint-PetersburgRussian Federation201215092014438087Copyright © Гурская О.Е., Галичева Е.В., Гайсина А.В., Рассохин В.В., Сизова Т.Д., Беляков Н.А., Медведев С.В., 20142014Гурская О.Е., Галичева Е.В., Гайсина А.В., Рассохин В.В., Сизова Т.Д., Беляков Н.А., Медведев С.В.Gurskaya O.E., Galicheva E.V., Gaisina A.V., Rassohin V.V., Sizova T.D., Beliakov N.A., Medvedev S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.niidi.ru/jofin/article/view/118

С целью раннего выявления субклинических когнитивных нарушений и поражения ЦНС у 20 пациентов с ВИЧ-инфекцией на ранних стадиях был проведен комплекс нейрофизиологических исследований: электроэнцефалограммы (ЭЭГ), когнитивных вызванных потенциалов мозга Р300 слуховой и зрительной модальностей, сложных сенсомоторных реакций, зрительных вызванных потенциалов и выявлены электрофизиологические признаки субклинических когнитивных нарушений и неспецифические электрофизиологические признаки субклинического поражения ЦНС. Применение расширенного комплекса электрофизиологических исследований с учетом специфики персистенции вируса в ЦНС позволило повысить чувствительность ранней диагностики субклинических когнитивных нарушений у ВИЧ-инфицированных больных до 90% случаев за счет оценки функции широко распространенных нейрональных сетей.

With a goal of the early detection of subclinical cognitive impairment and damage of the central nervous system in the early stages HIV infection the complex neurophysiological study (electroencephalogram, cognitive evoked potentials of auditory and visual modalities, complex sensory-motor reactions, visual evoked potentials) in 20 patients with HIV infection was performed. Electrophysiological signs of subclinical cognitive impairment and non-specific subclinical involvement of central nervous system were found. Application of the complex electrophysiological study by evaluating the function of widespread neuronal networks has allowed to increasing the sensitivity of early diagnosis of subclinical cognitive impairment in HIV-infected patients in 90% of cases.

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The authors declare that there are no conflicts of interest present.