References

jofin

Журнал инфектологии

Journal Infectology

2072-6732

IPO “АIDSSPbR"

10.22625/2072-6732-2012-4-3-5-15

jofin-108

Research Article

Обзоры

Review

СТРАТЕГИЯ УПРАВЛЕНИЯ БАКТЕРИАЛЬНЫМ БИОПЛЕНОЧНЫМ ПРОЦЕССОМ

Strategy of control for bacterial biofilm processes

Маянский

А. Н.

Mayansky

A. N.

заведующий кафедрой микробиологии и иммунологии Нижегородской государственной медицинской академии Минздравсоцразвития РФ, д.м.н., профессор; тел. (831)465-50-58; (831)434-73-51

mayansky@gma.nnov.ru

Чеботарь

И. В.

Chebotar

I. V.

доцент кафедры микробиологии и иммунологии Нижегородской государственной медицинской академии Минздравсоцразвития РФ, к.м.н.; тел. (831)465-42-71; +7-903-607-70-54

nizarnn@yandex.ru

Нижегородская государственная медицинская академия, Нижний НовгородРоссияNizhny Novgorod State Medical Academy, Nizhny NovgorodRussian Federation

2012

15092014

43515

2014

Маянский А.Н., Чеботарь И.В.

Mayansky A.N., Chebotar I.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.niidi.ru/jofin/article/view/108

Проанализированы основные направления современного поиска антибиопленочных препаратов, нацеленных на адгезивные реакции бактерий, управление QS-системами, воздействие на циклический димерный гуанозинмонофосфат (ц-ди-ГМФ), секреторные бактериальные процессы. Обсуждаются подходы, которые используются для отторжения биопленки и повышения чувствительности биопленочных бактерий к антимикробным средствам. Подчеркивается, что большинство ингибиторных молекул исследовалось in vitro или в опытах на инфицированных мышах. Прогнозируется появление медицинских препаратов, которые позволят бороться с бактериальными биопленками, предупреждая их развитие и распространение в организме хозяина.

Main directions of the modern search of the antibiofilm preparations aimed at adhesive bacterial reactions, control of QS-systems, influence over bis-(3’-5’)-cyclic dimeric guanosine monophosphate (cdi-GMP), and secretory bacterial processes are analysed. Approaches for biofilm dispersal and increasing the sensitivity of biofilm bacteria to antimicrobial drugs are discussed. It is underlined that the majority of inhibitor molecules were studied in vitro or in infected mice experiments. It is prognosed that in future there will appear medical preparations which will help for fighting bacterial biofilms preventing their development and spreading in the host organism.

биопленкибактерииадгезиясекрециярегуляцияотторжение

biofilmsbacteriaadhesionsecretionregulationrejection

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The authors declare that there are no conflicts of interest present.