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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jofin</journal-id><journal-title-group><journal-title xml:lang="ru">Журнал инфектологии</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Infectology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-6732</issn><publisher><publisher-name>IPO “АIDSSPbR"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.22625/2072-6732-2020-12-1-14-22</article-id><article-id custom-type="elpub" pub-id-type="custom">jofin-1008</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Акантамебные поражения роговицы (диагностика) (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>The acantamoeba lesions of the cornea (diagnosis)  (Review of literature)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каспаров</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kasparov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каспаров Аркадий Александрович – заведующий отделением патологии роговицы, д.м.н., профессор.</p><p> Москва, тел.: 8(499)248-06-75</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">kasparova_jane@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марченко</surname><given-names>Н. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Marchenko</surname><given-names>N. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марченко Николай Ростиславович – научный сотрудник отделения патологии роговицы, к.м.н.</p><p> Москва, тел.: 8(499)246-61-95</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">kmarchenko@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каспарова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kasparova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каспарова Евгения Аркадьевна – ведущий научный сотрудник отделения патологии роговицы, к.м.н.</p><p> Москва, тел.: 8(499)248-06-75</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">kasparova-jane@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт глазных болезней</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Eye Diseases, Moscow,</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт глазных болезней</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Eye Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>19</day><month>03</month><year>2020</year></pub-date><volume>12</volume><issue>1</issue><fpage>14</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каспаров А.А., Марченко Н.Р., Каспарова Е.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Каспаров А.А., Марченко Н.Р., Каспарова Е.А.</copyright-holder><copyright-holder xml:lang="en">Kasparov A.A., Marchenko N.R., Kasparova E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.niidi.ru/jofin/article/view/1008">https://journal.niidi.ru/jofin/article/view/1008</self-uri><abstract><p>Акантамебный кератит – нечастое, но крайне опасное заболевание роговицы; его чаще всего связывают с использованием контактных линз, а также микротравмами роговицы с последующим загрязением частицами почвы или воды. Заболевание редко характеризуется отличительными клиническими признаками, поэтому трудно отличимо от герпетического или грибкового кератита. Его, однако, можно заподозрить на основании анамнеза (ношение контактных линз, травма роговицы с контаминацией почвой или водой), выраженного болевого синдрома, инфильтрации роговицы в виде кольца, недостаточности эффекта традиционной терапии. Диагноз может быть уточнен при выделении возбудителя методом биокультуры, гистологическом исследовании биоптата роговицы методами световой и люминесцентной микроскопии, применении генной диаг ностики и прижизненной конфокальной микроскопии роговицы. Описаны перспективные методы диагностики акантамебного кератита. Однако до настоящего времени не существует стандартной методики диагностики этого заболевания.</p></abstract><trans-abstract xml:lang="en"><p>The Aсanthamoeba keratitis is a rare, but very dangerous disease of cornea; its development is connected with contact lens wearing, and corneal microtraumas with contamination of particles of the soil or water. The disease has no pronounced distinguishing clinical signs therefore it is difficult to distinguish them from herpetic or fungal keratitis. Nevertheless, it can be suspected on the basis of anamnestic data (use of contact lenses, corneal injury with contamination by the soil or water), uneven strong pain syndrome, ring-shaped infiltration of cornea, absence of effect of traditional therapy. Isolation of Acanthamoeba by bioculture method, morphological research of corneal bioptat (by light and luminescent microscopy), gene diagnostics, in – vivo confocal microscopy of the cornea can give additional help in the diagnosis. Also perspective diagnostic methods of Acanthamoeba keratitis are given. Nevertheless, so far there is no conventional technique of diagnosis of this disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>акантамеба</kwd><kwd>акантамебный кератит</kwd><kwd>контактные линзы</kwd><kwd>конфокальная микроскопия</kwd><kwd>полимеразная цепная реакция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Acanthamoeba</kwd><kwd>Acanthamoeba keratitis</kwd><kwd>contact lenses</kwd><kwd>confocal microscopy</kwd><kwd>polimerase chain reaction</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Uber die Verbreitung der Siisswasserprotozoen durch die Luft. /Puschkarew В. М. //Arch. Protistenk. -1913 .- Vol.28.- P323-362.</mixed-citation><mixed-citation xml:lang="en">Puschkarew В. М. Uber die Verbreitung der Siisswasserprotozoen durch die Luft. Arch. 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